Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema – Research
Xiao et al. identify α-KG as a rosacea-associated metabolite that activates the OXGR1-Gq-MYL9 axis in the vascular smooth muscle cells to boost contractility and suppress pathological vasodilation underlying erythema. Cryo-EM reveals a bipartite-acid pocket...
Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema – Research
Xiao et al. identify α-KG as a rosacea-associated metabolite that activates the OXGR1-Gq-MYL9 axis in the vascular smooth muscle cells to boost contractility and...
Somatic genomics as a discovery engine for biomedicine – Research
Somatic genetics uses tissue mutations to understand aging, reveal disease mechanisms, and guide new therapies.
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Tufts launches faculty pay transparency initiative following Massachusetts transparency law – The Tufts Daily – Open Positions
Tufts launches faculty pay transparency initiative following Massachusetts transparency law The Tufts Daily
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Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema – Research
Dr AF Saeed - 0
Xiao et al. identify α-KG as a rosacea-associated metabolite that activates the OXGR1-Gq-MYL9 axis in the vascular smooth muscle cells to boost contractility and...
Somatic genomics as a discovery engine for biomedicine – Research
Dr AF Saeed - 0
Somatic genetics uses tissue mutations to understand aging, reveal disease mechanisms, and guide new therapies.
Read more about this post...
Credits: Source
Disclaimer
Tufts launches faculty pay transparency initiative following Massachusetts transparency law – The Tufts Daily – Open Positions
Dr AF Saeed - 0
Tufts launches faculty pay transparency initiative following Massachusetts transparency law The Tufts Daily
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Administrative Operations Coordinator – Open Positions
Dr AF Saeed - 0
University of Kentucky (Lexington, KY)
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